One special "touristy" item is to ride the Rogue River on the Mail Boats. We made our reservations in advance and arrived early for the best seating (second or third rows best) on a 104 mile river cruise. The driver takes you for a ride, literally. He spins the boat around and you will get wet. Not drenched, just comfortably refreshed. Along the way you'll see a dozen types of wildlife, including bald eagles, osprey, deer, turtles, salmon, vultures, and sometimes bear. You'll also see kayakers and some even will squirt you with their water guns. They stop for lunch in Agness and it's an all day affair.
Other things not to miss, tidepool walks on the beach, redwoods in Jedidiah National Park, Trees of Mystery south of Crescent City, and going 100 miles north of Brookings you'll find the best fresh grilled seafood ever at Portside Restaurant in Coos Bay. Drive through Coos Bay, turn left, and take the five mile drive to the beautiful gardens, sea lions, and lighthouse. It's worth it.
Let Dr. Travelbest know if you're heading up there anytime soon.